Antibodies against clumping factor of Staphylococcus aureus in patients with osteopurulent infection
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چکیده
منابع مشابه
Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection
In a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016, http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of the Staphylococcus aureus protein clumping factor A (ClfA) in protecting mice from S. aureus infection. ClfA, one of the first proteins to be identified as a potential vaccine antigen for S. aureus prophylaxis, is currently a component of severa...
متن کاملProtection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant.
The importance of the fibrinogen-binding adhesin clumping factor A (ClfA) in the pathogenesis of Staphylococcus aureus septic arthritis was examined in an animal model. The protective effect of active and passive immunization with ClfA also was investigated in S. aureus infection models. The severity of arthritis was markedly reduced in mice challenged intravenously with a clfA mutant, compared...
متن کاملEvidence against concerted evolution in a tandem array in the clumping factor gene of Staphylococcus aureus.
Naturally occurring tandemly repeat sequences are widely distributed among eukaryotes. Their evolution is characterized by genetic instability, which may arise from slippage, unequal crossover, and gene conversion (Charlesworth et al. 1994); this instability is seen in noncoding DNA (Jeffreys et al. 1994), RNA-coding genes (reviewed in Li and Graur 199 1, pp. 162169), and protein-coding genes (...
متن کاملEsxA might as a virulence factor induce antibodies in patients with Staphylococcus aureus infection
Staphylococcus aureus (S. aureus) is an important human pathogen, which commonly causes the acquired infectious diseases in the hospital and community. Effective and simple antibiotic treatment against S. aureus-related disease becomes increasingly difficult. Developing a safe and effective vaccine against S. aureus has become one of the world's hot spots once again. The key issue of developing...
متن کاملPreclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection
UNLABELLED Treatment of Staphylococcus aureus infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Development of a vaccine to prevent staphylococcal infections remains a priority. To determine whether clumping factor A (ClfA) is a good target protein for inclusion in a multivalent vaccine, we evaluated its efficacy in a variety of relevant stap...
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2002
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.000625